The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 07, 2010
Filed:
May. 25, 2004
Juan Botas, Houston, TX (US);
Diego Rincon-limas, Galveston, TX (US);
Pedro Fernandez-funez, Galveston, TX (US);
Ismael Al-ramahi, Houston, TX (US);
Juan Botas, Houston, TX (US);
Diego Rincon-Limas, Galveston, TX (US);
Pedro Fernandez-Funez, Galveston, TX (US);
Ismael Al-Ramahi, Houston, TX (US);
Baylor College of Medicine, Houston, TX (US);
Abstract
The present invention discloses a double transgenic fly that expresses both Tau protein and the human Aβ42 peptide of human amyloid-β precursor protein (APP). The double transgenic flies of the present invention display a synergistic altered phenotype as compared to the altered phenotype displayed by transgenic flies expressing either Tau or human Aβ42 alone, and thus provide for an improved model for neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying for therapeutic compounds to treat neurodegenerative disorders using the double transgenic flies.