The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 07, 2010
Filed:
Oct. 21, 2009
Ashok Kumar, Mumbai, IN;
Suneel Yeshwant Dike, Maharashtra, IN;
Pramil Kumar Mathur, Mumbai, IN;
Nellithanath Thankachen Byju, Mumbai, IN;
Brajesh Sharma, Mumbai, IN;
Swapnil Shreekant Kore, Mumbai, IN;
Vitthal Suryabhan Buchude, Mumbai, IN;
Dharmendra Singh, Thane, IN;
Ashok Kumar, Mumbai, IN;
Suneel Yeshwant Dike, Maharashtra, IN;
Pramil Kumar Mathur, Mumbai, IN;
Nellithanath Thankachen Byju, Mumbai, IN;
Brajesh Sharma, Mumbai, IN;
Swapnil Shreekant Kore, Mumbai, IN;
Vitthal Suryabhan Buchude, Mumbai, IN;
Dharmendra Singh, Thane, IN;
IPCA Laboratories Limited, Mumbai, IN;
Abstract
Disclosed herein is a novel process for preparation of atovaquone. The process includes reacting 1,4-naphthoquinone with trans-4-(4-chlorophenyl) cyclohexane carboxylic acid followed by halogenation to obtain a dihalo-compound. Further, dehydrohalogenation of the dihalo-compound produces a monohalogeno-compound which under goes hydrolysis to produce atovaquone. The invention also discloses atovaquone in a substantially pure and well defined polymorphic form designated as 'Form IPCA-ATO,' and the preparation thereof.