The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 07, 2010
Filed:
Aug. 13, 2009
Frank Seela, Osnabrueck, DE;
Helmut Rosemeyer, Osnabrueck, DE;
Enno Schweinberger, Oberweser, DE;
Dieter Heindl, Paehl, DE;
Frank Bergmann, Iffeldorf, DE;
Frank Seela, Osnabrueck, DE;
Helmut Rosemeyer, Osnabrueck, DE;
Enno Schweinberger, Oberweser, DE;
Dieter Heindl, Paehl, DE;
Frank Bergmann, Iffeldorf, DE;
Roche Molecular Systems, Inc., Pleasanton, CA (US);
Abstract
Within oligonucleotides, 2-azapurine and especially 2-azaadenine bases form specifically base pairs with guanine. This base pair is of analogous stability as an adenine-thymine but less stable than a guanine-cytosine base pair. Therefore, the incorporation of 2-azaadenine residues into oligonucleotides instead of cytosine leads specifically to hybridization complexes with nucleic acids with homogenous stability. This is useful for the adaptation of the stabilities of different oligonucleotide sequences in all kinds of hybridization techniques, for example in oligomer chip technology.