The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 07, 2010

Filed:

May. 11, 2007
Applicants:

Pingda Ren, San Diego, CA (US);

Baogen Wu, San Diego, CA (US);

Guobao Zhang, San Diego, CA (US);

Yongping Xie, San Diego, CA (US);

Barun Okram, San Diego, CA (US);

Victor Nikulin, Carlsbad, CA (US);

Xia Wang, San Diego, CA (US);

Ha-soon Choi, San Diego, CA (US);

Inventors:

Pingda Ren, San Diego, CA (US);

Baogen Wu, San Diego, CA (US);

Guobao Zhang, San Diego, CA (US);

Yongping Xie, San Diego, CA (US);

Barun Okram, San Diego, CA (US);

Victor Nikulin, Carlsbad, CA (US);

Xia Wang, San Diego, CA (US);

Ha-Soon Choi, San Diego, CA (US);

Assignee:

IRM LLC, Hamilton, BM;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/00 (2006.01); A61K 31/54 (2006.01);
U.S. Cl.
CPC ...
Abstract

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, Bcr-Abl(T315I), ALK, BLK, BMX, BRK, C-kit, c-RAF, CSK, c-SRC, EGFR, Fes, FGFR3, Flt3, Fms, Fyn, IGF-1R, IR, JAK(2), JAK(3), KDR, Lck, NLK, p70S6K, PDGFRα, Ros, SAPK2α, SGK, SIK, Syk, Tie2 and TrkB kinases.


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