The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 23, 2010
Filed:
Nov. 14, 2006
Qiufen Xue, Newbury Park, CA (US);
Brian K. Albrecht, Cambridge, MA (US);
Denise Lyn Andersen, Simi Valley, CA (US);
Michael Bartberger, Sherman Oaks, CA (US);
James Brown, Moorpark, CA (US);
Ryan Brown, Belmont, MA (US);
Stuart C. Chaffee, Philadelphia, PA (US);
Yuan Cheng, Newbury Park, CA (US);
Michael Croghan, Thousand Oaks, CA (US);
Russell Graceffa, Hampton, NH (US);
Scott Harried, Woodland Hills, CA (US);
Stephen Hitchcock, Westlake Village, CA (US);
Randall Hungate, Camarillo, CA (US);
Ted Judd, Simi Valley, CA (US);
Matthew Kaller, Ventura, CA (US);
Charles Kreiman, Watertown, MA (US);
Daniel LA, Brookline, MA (US);
Patricia Lopez, West Hills, CA (US);
Craig Masse, Cambridge, MA (US);
Holger Monenschein, Camarillo, CA (US);
Thomas Nguyen, Thousand Oaks, CA (US);
Thomas Nixey, Newbury Park, CA (US);
Vinod F. Patel, Acton, MA (US);
Lewis Pennington, Camarillo, CA (US);
Matthew Weiss, Boston, MA (US);
Bryant Yang, Simi Valley, CA (US);
Wenge Zhong, Thousand Oaks, CA (US);
Qiufen Xue, Newbury Park, CA (US);
Brian K. Albrecht, Cambridge, MA (US);
Denise Lyn Andersen, Simi Valley, CA (US);
Michael Bartberger, Sherman Oaks, CA (US);
James Brown, Moorpark, CA (US);
Ryan Brown, Belmont, MA (US);
Stuart C. Chaffee, Philadelphia, PA (US);
Yuan Cheng, Newbury Park, CA (US);
Michael Croghan, Thousand Oaks, CA (US);
Russell Graceffa, Hampton, NH (US);
Scott Harried, Woodland Hills, CA (US);
Stephen Hitchcock, Westlake Village, CA (US);
Randall Hungate, Camarillo, CA (US);
Ted Judd, Simi Valley, CA (US);
Matthew Kaller, Ventura, CA (US);
Charles Kreiman, Watertown, MA (US);
Daniel La, Brookline, MA (US);
Patricia Lopez, West Hills, CA (US);
Craig Masse, Cambridge, MA (US);
Holger Monenschein, Camarillo, CA (US);
Thomas Nguyen, Thousand Oaks, CA (US);
Thomas Nixey, Newbury Park, CA (US);
Vinod F. Patel, Acton, MA (US);
Lewis Pennington, Camarillo, CA (US);
Matthew Weiss, Boston, MA (US);
Bryant Yang, Simi Valley, CA (US);
Wenge Zhong, Thousand Oaks, CA (US);
Amgen Inc., Thousand Oaks, CA (US);
Abstract
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein R, W, B, R, R, R, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.