The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 23, 2010
Filed:
May. 02, 2005
Applicants:
Eric H. Baehrecke, University Park, MD (US);
Ajjai Alva, Baltimore, MD (US);
Michael J. Lenardo, Potomac, MD (US);
Yu LI, Rockville, MD (US);
Inventors:
Eric H. Baehrecke, University Park, MD (US);
Ajjai Alva, Baltimore, MD (US);
Michael J. Lenardo, Potomac, MD (US);
Yu Li, Rockville, MD (US);
Assignees:
University of Maryland College Park, College Park, MD (US);
National Institutes of Health, Bethesda, MD (US);
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); C07K 16/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention relates to a new molecular pathway in which activation of the receptor-interacting protein (RIP, a serine-threonine kinase) and Jun N-terminal kinase induce cell death with the morphology of autophagy. Further, autophagic death is induced by caspase 8 inhibition and expression of the mammalian genes ATG7 and beclin.