The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 23, 2010
Filed:
Nov. 12, 2003
Alison Hannah, Sebastopol, CA (US);
Eric Harwood, Seattle, WA (US);
Peter Haroldsen, Pacifica, CA (US);
Carla Heise, Benecia, CA (US);
Timothy Machajewski, Martinez, CA (US);
Emil Samara, Danville, CA (US);
Xiao Shang, Bellevue, WA (US);
Jayesh Vora, Martinez, CA (US);
Shuguang Zhu, Seattle, WA (US);
Alison Hannah, Sebastopol, CA (US);
Eric Harwood, Seattle, WA (US);
Peter Haroldsen, Pacifica, CA (US);
Carla Heise, Benecia, CA (US);
Timothy Machajewski, Martinez, CA (US);
Emil Samara, Danville, CA (US);
Xiao Shang, Bellevue, WA (US);
Jayesh Vora, Martinez, CA (US);
Shuguang Zhu, Seattle, WA (US);
Novartis Vaccines and Diagnostics, Inc., Emeryville, CA (US);
Abstract
Methods of treating cancer using 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one are provided. In particular, the methods are effective for the treatment of solid tumors or leukemias, including prostate, colorectal, breast, multiple myeloma, pancreatic, small cell carcinoma, acute myelogenous leukemia, chronic myelogenous leukemia, or myelo-proliferative disease. Further provided are methods of measuring the amount of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one and determining a metabolic profile therefore.