The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 23, 2010
Filed:
Jun. 14, 2006
Frederick W. Alt, Cambridge, MA (US);
David B. Lombard, Cambridge, MA (US);
Katrin F. Chua, Palo Alto, CA (US);
Raul Mostoslavsky, Boston, MA (US);
Hwei-ling Cheng, Northborough, MA (US);
Frederick W. Alt, Cambridge, MA (US);
David B. Lombard, Cambridge, MA (US);
Katrin F. Chua, Palo Alto, CA (US);
Raul Mostoslavsky, Boston, MA (US);
Hwei-Ling Cheng, Northborough, MA (US);
Children's Medical Center Corporation, Boston, MA (US);
Abstract
The present invention is directed to methods for enhancing the replicative capacity of cells, by culturing the cells in the presence of an active agent or compound which inhibits SIRT1. One method provides expanding stem cells by culturing the cells in the presence of a SIRT1 inhibitor. The resulting cultured cells can be used for a variety of applications including cell-based therapies such as bone marrow transplants, gene therapies, tissue engineering, and in vitro organogenesis.