The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 23, 2010
Filed:
May. 27, 2010
Samuel R. Denmeade, Ellicott City, MD (US);
John T. Isaacs, Phoenix, MD (US);
J. Thomas Buckley, Victoria, CA;
Samuel R. Denmeade, Ellicott City, MD (US);
John T. Isaacs, Phoenix, MD (US);
J. Thomas Buckley, Victoria, CA;
University of Victoria Innovation and Development Corporation, Victoria, BC, CA;
The Johns Hopkins University, Baltimore, MD (US);
Abstract
Disclosed herein are modified proaerolysin (PA) peptide. In some examples, the proteins include a prostate-specific protease cleavage site and can further include a prostate-tissue-specific binding domain which functionally replaces the native PA binding domain. In other examples, the proteins include a furin cleavage site and a prostate tissue-specific binding domain which functionally replaces the native PA binding domain. Methods of using such peptides to treat prostate cancer are also disclosed.