The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 23, 2010
Filed:
Feb. 23, 2007
Applicants:
Donald W. Miller, Winnepeg, CA;
Corbin J. Bachmeier, Minot, ND (US);
Richard B. Lomneth, Omaha, NE (US);
Inventors:
Donald W. Miller, Winnepeg, CA;
Corbin J. Bachmeier, Minot, ND (US);
Richard B. Lomneth, Omaha, NE (US);
Assignee:
Board of Regents of the University of Nebraska, Lincoln, NE (US);
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/53 (2006.01); C40B 30/04 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention relates to high-throughput cell-based assays for real-time monitoring of multi-resistant drug protein activity. The present invention is an improvement over existing assays in that in addition to a fluorescent drug efflux probe as an indicator of MDR protein activity, the instant assays provide an o-tolidine-based dye for quenching extracellular fluorescence of the probe.