Synthetic peptides useful in biological essays for detecting infections caused by group o hiv-1 viruses

Abstract

Synthetic peptides of the monomer type with 13 to 33 amino acids, in linear form or in a form cyclized by means of inter-cysteine disulphide bridges, have the general formula (I):Δ-Z-TrpGlyCys-Θ-CysTyrThrSer-Ω  (I)wherein Δ is a biotinyl radical, a biocytinyl radical, a hydrogen atom, an acetyl (CHCO—) radical, an aliphatic chain which may contain one or two thiol, an aldehyde functional group, or an amine functional group, Z represents peptide sequence -Ξ-Ser-Ξ-, -Ξ-Gln-Ξ-, or -Ξ-Asn-Ξ-, wherein -Ξrepresents a peptide sequence of 0 to 9 amino acids and -Ξrepresents a peptide sequence of 0 to 5 amino acids, Θis -Arg Gly Arg Leu Ile-(SEQ ID NO: 15), -Arg Gly Arg Leu Val-(SEQ ID NO: 16), -Arg Gly Lys Leu Ile-(SEQ ID NO: 17), -Arg Gly Lys Leu Val-(SEQ ID NO: 18), -Lys Gly Arg Leu Ile-(SEQ ID NO: 19), or -Lys Gly Arg Leu Val-(SEQ ID NO: 20), Ω, attached to the —CO— group of serine, is a hydroxyl (—OH) radical, an amino (—NH) radical, an alkoxy radical having 1 to 6 carbon atoms, a peptide sequence of formula Val-Σ-Ψ wherein Σ represents a sequence of formula -(AA)-Trp Asn-(AA)-(AA) wherein (AA) represents an amino acid different from lysine, (AA) represents an amino acid, and (AA) is serine or a threonine residue, and Ψ, attached to the —CO— residue of the free AAamino acid, is OH, NH, or an alkoxy radical having from 1 to 6 carbon atoms, and a peptide sequence of formula -Val-Ψ wherein Ψ, attached to the —CO— residue of valine, is OH, NH, or an alkoxy radical having from 1 to 6 carbon atoms.