The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 16, 2010
Filed:
Aug. 01, 2006
Applicants:
Matthew Bio, Boston, MA (US);
Karel Marie Joseph Brands, Jersey City, NJ (US);
Edward Cleator, Cambridge, GB;
Inventors:
Matthew Bio, Boston, MA (US);
Karel Marie Joseph Brands, Jersey City, NJ (US);
Edward Cleator, Cambridge, GB;
Assignee:
Merck Sharp & Dohme Ltd., Hoddesdon, GB;
Primary Examiner:
Int. Cl.
CPC ...
C07C 35/27 (2006.01);
U.S. Cl.
CPC ...
Abstract
A process for the preparation of a the formula (I): which process comprises the intramolecular cyclopropanation of an epoxide of me formula (II); in the presence of 0.05 to 0.75 equivalents of a secondary amine base and at least one equivalent of an alkyl lithium base, wherein R R, Rand Rare each hydrogen or Calkyl or Rand Rare linked to form- a CcycloaUcyl or Ccycloalkenyl ring.