The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 16, 2010
Filed:
Dec. 16, 2005
Thomas Daniel Aicher, Superior, CO (US);
Mark Joseph Chicarelli, Longmont, CO (US);
Ronald Jay Hinklin, Longmont, CO (US);
Hongqi Tian, Longmont, CO (US);
Owen Brendan Wallace, Zionsville, IN (US);
Thomas Daniel Aicher, Superior, CO (US);
Mark Joseph Chicarelli, Longmont, CO (US);
Ronald Jay Hinklin, Longmont, CO (US);
Hongqi Tian, Longmont, CO (US);
Owen Brendan Wallace, Zionsville, IN (US);
Eli Lilly and Company, Indianapolis, IN (US);
Abstract
The present invention provides compounds of formula I that are useful as potent and selective inhibitors of 11-beta hydroxysteroid dehydrogenase 1. The present invention further provides a pharmaceutical composition which comprises a compound of Formula I, or a pharmaceutical salt thereof, and a pharmaceutically acceptable carrier, diluent, or excipient. In addition, the present invention provides compositions comprising compounds of formula I for the treatment of metabolic syndrome, diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, other symptoms associated with hyperglycemia, and related disorders. Formula (I) wherein, Ris (II), or (III) Gis methylene or ethylene; L is a divalent linking group selected from —(C-C) alkylene-, —S—, —CH(OH)—, or —O—; A is methylene, —S—, —O—, or —NH—; and the other substituents are as defined in the claims.