The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 16, 2010
Filed:
Sep. 08, 2006
David Peretz, El Cerrito, CA (US);
Michael D. Connolly, Dublin, CA (US);
Ronald Zuckermann, El Cerrito, CA (US);
Man Gao, San Ramon, CA (US);
Gulliver Timoteo, Hayward, CA (US);
Robert M. Shimizu, Petaluma, CA (US);
David Peretz, El Cerrito, CA (US);
Michael D. Connolly, Dublin, CA (US);
Ronald Zuckermann, El Cerrito, CA (US);
Man Gao, San Ramon, CA (US);
Gulliver Timoteo, Hayward, CA (US);
Robert M. Shimizu, Petaluma, CA (US);
Novartis AG, Basel, CH;
Abstract
The invention relates to peptoid reagents that interact preferentially with a pathogenic form of a conformational disease protein as compared to a nonpathogenic form of the conformational disease protein where the peptoid reagent comprises an amino-terminal region, a carboxy-terminal region, and at least one peptoid region between the amino-terminal region and the carboxy-terminal region where the peptoid region comprises 3 to about 30 N-substituted glycines, and optionally one or more amino acids. The invention also relates to methods of using the peptoids in detecting and isolating prions, and in the treatment and prevention of prion-related diseases.