The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 16, 2010
Filed:
Jun. 15, 2005
Bandi Parthasaradhi Reddy, Hyderabad, IN;
Kura Rathnakar Reddy, Hyderabad, IN;
Rapolu Raji Reddy, Hyderabad, IN;
Dasari Muralidhara Reddy, Hyderabad, IN;
Bandi Parthasaradhi Reddy, Hyderabad, IN;
Kura Rathnakar Reddy, Hyderabad, IN;
Rapolu Raji Reddy, Hyderabad, IN;
Dasari Muralidhara Reddy, Hyderabad, IN;
Hetero Drugs Limited, Hyderabad, IN;
Abstract
The present invention provides a novel process for the preparation of gemifloxacin and its pharmaceutically acceptable acid addition salts in high yield. The present invention also relates to novel polymorphs of gemifloxacin free base and its hydrates to the processes for their preparation and to pharmaceutical compositions comprising them. The present invention also relates to infusion solutions of gemifloxacin and to processes for their preparation. Thus, 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1, 8-naphthyridine-3-carboxylic acid is reacted with a mixture of acetic anhydride, acetic acid and boric acid to give borane compound, which is then treated with 4-Aminomethyl-3-methoxyimino-pyrrolidinium dimethanesulfonate in presence of triethylamine, followed by treatment with 3.5% sodium hydroxide solution to give gemifloxacin free base.