The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 16, 2010

Filed:

Dec. 03, 2008
Applicants:

Mitsuru Ohkubo, Ushiku, JP;

Tetsuya Kato, Tsukuba, JP;

Nobuhiko Kawanishi, Moriya, JP;

Takashi Mita, Tsukuba, JP;

Toshiyasu Shimomura, Tsukuba, JP;

Inventors:

Mitsuru Ohkubo, Ushiku, JP;

Tetsuya Kato, Tsukuba, JP;

Nobuhiko Kawanishi, Moriya, JP;

Takashi Mita, Tsukuba, JP;

Toshiyasu Shimomura, Tsukuba, JP;

Assignee:

Banyu Pharmaceutical Co., Ltd, Chiyoda-Ku Tokyo, JP;

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/497 (2006.01); C07D 241/04 (2006.01); C07D 295/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention relates to a compound represented by the general formula (I): wherein mand mare 1, 2, or 3; nand nare 0 or 1; i is an integer of any of 1 to m; j is an integer of 1 to m; R is aryl, heteroaryl, or cycloalkyl any of which may be substituted; Rand R' is hydrogen atom, etc. and Rand R′ is hydrogen atom, etc.; R, R, and Rare hydrogen atom, etc; Xis CH, CX, or N; Xis CH, N, etc.; Xis CH, N, etc.; Xis CH or N; Y, Y, and Yare each independently CH or N; Zand Zare each independently CH or N; W is a 5-membered aromatic heterocyclic group such as pyrazolyl, thiazolyl, etc., or a pharmaceutically acceptable salt or ester thereof; a pharmaceutical composition or antitumor agent containing the same; and combinations of the antitumor agent with other antitumor agent(s).


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