The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 09, 2010

Filed:

Sep. 15, 2005
Applicants:

Arlindo L. Castelhano, Farmingdale, NY (US);

Andrew Crew, Farmingdale, NY (US);

Hanqing Dong, Farmingdale, NY (US);

An-hu LI, Farmingdale, NY (US);

LI Qiu, West Lafayette, IN (US);

Alun Smith, Birmingham, GB;

Lawrence Tardibono, Mishawaka, IN (US);

Tao Zhang, Dix Hills, NY (US);

Inventors:

Arlindo L. Castelhano, Farmingdale, NY (US);

Andrew Crew, Farmingdale, NY (US);

Hanqing Dong, Farmingdale, NY (US);

An-Hu Li, Farmingdale, NY (US);

Li Qiu, West Lafayette, IN (US);

Alun Smith, Birmingham, GB;

Lawrence Tardibono, Mishawaka, IN (US);

Tao Zhang, Dix Hills, NY (US);

Assignee:

OSI Pharmaceuticals, Inc., Ardsley, NY (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 215/12 (2006.01); A61K 31/47 (2006.01);
U.S. Cl.
CPC ...
Abstract

Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein A, Q, Y, R, m and J are defined herein, are useful in the treatment of tumors and cancers such as mastocytosis/mast cell leukemia, gastrointestinal stromal tumors (GIST), germ cell tumors, small cell lung carcinoma (SCLC), sinonasal natural killer/T-cell lymphoma, testicular cancer (seminoma), thyroid carcinoma, malignant melanoma, ovarian carcinoma, adenoid cystic carcinoma, acute myelogenous leukemia (AML), breast carcinoma, pediatric T-cell acute lymphoblastic leukemia, neuroblastoma, mast cell leukemia, angiosarcoma, anaplastic large cell lymphoma, endometrial carcinoma, and prostate carcinoma.


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