The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 09, 2010
Filed:
Aug. 14, 2009
Applicants:
James A. Ernst, San Francisco, CA (US);
Daniel Yansura, Pacifica, CA (US);
Hok Seon Kim, San Francisco, CA (US);
Inventors:
James A. Ernst, San Francisco, CA (US);
Daniel Yansura, Pacifica, CA (US);
Hok Seon Kim, San Francisco, CA (US);
Assignee:
Genentech, Inc., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/36 (2006.01); C12N 15/70 (2006.01); C12N 15/72 (2006.01); C12N 15/09 (2006.01); C12N 15/71 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
Methods for producing membrane-spanning polypeptides in high yields, with native conformation, and/or in soluble form include solubilizing in non-ionic or zwitterionic detergents, as well as use of promoters and expression vectors for expressing high yields of membrane-spanning polypeptides in bacterial cells. Mutated promoters provide tight control of membrane-spanning polypeptides in bacterial cell hosts.