The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 09, 2010
Filed:
Dec. 05, 2006
Michael K. Riscoe, Tualatin, OR (US);
Rolf W. Winter, Portland, OR (US);
Jane X. Kelly, Lake Oswego, OR (US);
Martin J. Smilkstein, Portland, OR (US);
David J. Hinrichs, Lake Oswego, OR (US);
Michael K. Riscoe, Tualatin, OR (US);
Rolf W. Winter, Portland, OR (US);
Jane X. Kelly, Lake Oswego, OR (US);
Martin J. Smilkstein, Portland, OR (US);
David J. Hinrichs, Lake Oswego, OR (US);
Oregon Health & Science University, Portland, OR (US);
U.S. Department of Veterans Affairs, Washington, DC (US);
Abstract
Aromatic ketones having an extended fluoro-alkyl or fluoro-alkoxy moiety are disclosed. In particular aspects, the compounds comprise substituted 9-acridone, 9-xanthone, 4(1H)-quinolone, 4(1H) pyridone, 1,4-naphthoquinone, 9,10-anthraquinone derivatives. These preparations possess potent pharmacological activity for inhibiting malaria and mosquito-borne () diseases. The haloalkyl/alkoxy aromatic compounds possess significant pharmacological activity, with ICvalues in the nanomolar and sub-nanomolar range, and reduced toxicity against host derived cells and tissues. Methods of using the fluoro-alkyl/alkoxy aromatic compounds in the treatment of malaria and other human and animal diseases are also disclosed. Agricultural uses of the fluoro-alkyl/alkoxy aromatic compounds, such as in control of fungal diseases and in the production of important commercial crops (apples, etc.), are also presented.