The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 09, 2010
Filed:
Oct. 04, 2007
Mary T. Didiuk, Madison, CT (US);
Kevin K. Liu, East Lyme, CT (US);
David A. Griffith, Old Saybrook, CT (US);
Angel Guzman-perez, Mystic, CT (US);
Feng C. BI, Groton, CT (US);
Daniel P. Walker, Chesterfield, MO (US);
Mary T. Didiuk, Madison, CT (US);
Kevin K. Liu, East Lyme, CT (US);
David A. Griffith, Old Saybrook, CT (US);
Angel Guzman-Perez, Mystic, CT (US);
Feng C. Bi, Groton, CT (US);
Daniel P. Walker, Chesterfield, MO (US);
Pfizer Inc, New York, NY (US);
Abstract
The present invention is directed to novel pyrido[4,3-d]pyrimidin-4(3H)-one derivatives and pharmaceutically acceptable salts thereof of structural formula I wherein the variables R, R, R, Rand Rare as described herein. Also provided are pharmaceutical compositions comprising the compounds of formula I as well as methods of treatment employing compounds of formula I to treat a disease or disorder characterized by abnormal bone or mineral homeostasis such as hypoparathyroidism, osteoporosis, osteopenia, periodontal disease, Paget's disease, bone fracture, osteoarthritis, rheumatoid arthritis, and humoral hypercalcemia of malignancy.