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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 7829563 B1

PDFFull Text
Date of Patent:
Nov. 09, 2010

Filed:

Feb. 27, 2008

Aminoamides as orexin antagonists

Applicants:

Luca Gobbi, Oberwil BL, CH;

Henner Knust, Rheinfelden, DE;

Parichehr Malherbe, Muttenz, CH;

Matthias Nettekoven, Grenzach-Wyhlen, DE;

Emmanuel Pinard, Linsdorf, FR;

Olivier Roche, Folgensbourg, FR;

Mark Rogers-evans, Oberwil BL, CH;

Inventors:

Luca Gobbi, Oberwil BL, CH;

Henner Knust, Rheinfelden, DE;

Parichehr Malherbe, Muttenz, CH;

Matthias Nettekoven, Grenzach-Wyhlen, DE;

Emmanuel Pinard, Linsdorf, FR;

Olivier Roche, Folgensbourg, FR;

Mark Rogers-Evans, Oberwil BL, CH;

Assignee:

Hoffmann-La Roche Inc., Nutley, NJ (US);

Attorneys:

George W. Johnston

Patricia S. Rocha-Tramaloni

Kimberly J. Prior

Primary Examiner:

Sreeni Padmanabhan

Assistant Examiner:

Sarah Pihonak

Int. Cl.
CPC ...
A61K 31/50 (2006.01); A61K 31/501 (2006.01); A61K 31/497 (2006.01); A01N 43/54 (2006.01); C07D 239/42 (2006.01); C07D 401/04 (2006.01); A01N 43/40 (2006.01); A61K 31/435 (2006.01); A01N 43/78 (2006.01); A61K 31/425 (2006.01); A01N 43/50 (2006.01); A61K 31/415 (2006.01); A01N 43/56 (2006.01); A01N 43/08 (2006.01); A61K 31/34 (2006.01); C07D 279/00 (2006.01); C07D 285/00 (2006.01); C07D 401/00 (2006.01); C07D 421/00 (2006.01); C07D 419/00 (2006.01); C07D 277/04 (2006.01); C07D 277/08 (2006.01); C07D 409/00 (2006.01); C07D 335/00 (2006.01); C07D 333/02 (2006.01); C07D 321/00 (2006.01); C07D 307/00 (2006.01); C07D 317/00 (2006.01); C07D 323/02 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention relates to compounds of formula I wherein Ar, Ar, Ar, n, andRto Rare as defined herein and to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. These compounds are orexin receptor antagonists and may be useful in the treatment of disorders, in which orexin pathways are involved, like sleep disorders.

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