The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 09, 2010
Filed:
Feb. 13, 1998
David Blake, Aylesbury, GB;
Declan Naughton, Badminton, GB;
Ged Adams, Wheatley, GB;
Margaret Adams, Legal Representative, Holton, GB;
Ian Stratford, Hope Valley, GB;
Christopher Morris, Chippenham, GB;
Mohammed Jaffar, Withington, GB;
Matthew Naylor, West Cheshunt, GB;
David Blake, Aylesbury, GB;
Declan Naughton, Badminton, GB;
Ged Adams, Wheatley, GB;
Margaret Adams, legal representative, Holton, GB;
Ian Stratford, Hope Valley, GB;
Christopher Morris, Chippenham, GB;
Mohammed Jaffar, Withington, GB;
Matthew Naylor, West Cheshunt, GB;
The University of Manchester, Manchester, GB;
Abstract
The invention provides a method of targeting a drug to areas of hypoxic and/or ischemic tissue within the body in which the desired drug species is linked to a non-cytotoxic bioreductive carrier. Also provided by the invention are novel bioreductive conjugates comprising a non-cytotoxic bioreductive moiety with linked-thereto at least one therapeutic agent. The compounds of the invention are particularly suitable for the treatment of rheumatoid arthritis and other arthritic conditions, diabetes, atherosclerosis, stroke, sepsis, Alzheimer's disease and other neurological disorders, cancer, kidney disease, digestive diseases, liver disease, chronic periodontitis or ischemia following tissue transplantation.