The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 09, 2010
Filed:
Feb. 05, 2009
Applicants:
Neil Lee Spector, Durham, NC (US);
Wenle Xia, Durham, NC (US);
Inventors:
Neil Lee Spector, Durham, NC (US);
Wenle Xia, Durham, NC (US);
Assignee:
GlaxoSmithKline LLC, Philadelphia, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); C07K 2/00 (2006.01); C07K 4/00 (2006.01); C07K 5/00 (2006.01); C07K 7/00 (2006.01); C07K 14/00 (2006.01); C07K 16/00 (2006.01); C07K 17/00 (2006.01); A01N 37/18 (2006.01);
U.S. Cl.
CPC ...
Abstract
The truncated ErbB2 receptor (p95) is shown to differ from the full-length ErbB2 receptor in its association with other ErbB receptors. The truncated receptor preferentially associated with ErbB3, whereas full length ErbB2 heterodimerizes with either EGFR or ErbB3. Consistent with p95heterodimerization with ErbB3, it is shown that heregulin (an ErbB3 ligand) stimulates p95phosphorylation in breast cancer cell lines. Described herein are methods of identifying patients suitable for treatment with a p95inhibitor, and methods of treating such patients.