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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 7829063 B1

PDFFull Text
Date of Patent:
Nov. 09, 2010

Filed:

Apr. 07, 2008

Development of molecular imaging probes for carbonic anhydrase-ix using click chemistry

Applicants:

Hartmuth C. Kolb, Playa Del Rey, CA (US);

Joseph C. Walsh, Pacific Palisades, CA (US);

Dhanalakshmi Kasi, Los Angeles, CA (US);

Vani P. Mocharla, Los Angeles, CA (US);

Bing Wang, San Jose, CA (US);

Umesh B. Gangadharmath, Los Angeles, CA (US);

Brian A. Duclos, Kalamazoo, MI (US);

Kai Chen, Los Angeles, CA (US);

Wei Zhang, Los Angeles, CA (US);

Gang Chen, Los Angeles, CA (US);

Henry Clifton Padgett, Hermosa Beach, CA (US);

Farhad Karimi, Canton, MA (US);

Peter J. H. Scott, Marina-del-Ray, CA (US);

Zhiyong Gao, Los Angeles, CA (US);

Qianwa Liang, Hacienda Heights, CA (US);

Thomas Lee Collier, Perkasie, PA (US);

Tieming Zhao, Los Angeles, CA (US);

Chunfang Xia, Los Angeles, CA (US);

Inventors:

Hartmuth C. Kolb, Playa Del Rey, CA (US);

Joseph C. Walsh, Pacific Palisades, CA (US);

Dhanalakshmi Kasi, Los Angeles, CA (US);

Vani P. Mocharla, Los Angeles, CA (US);

Bing Wang, San Jose, CA (US);

Umesh B. Gangadharmath, Los Angeles, CA (US);

Brian A. Duclos, Kalamazoo, MI (US);

Kai Chen, Los Angeles, CA (US);

Wei Zhang, Los Angeles, CA (US);

Gang Chen, Los Angeles, CA (US);

Henry Clifton Padgett, Hermosa Beach, CA (US);

Farhad Karimi, Canton, MA (US);

Peter J. H. Scott, Marina-del-Ray, CA (US);

Zhiyong Gao, Los Angeles, CA (US);

Qianwa Liang, Hacienda Heights, CA (US);

Thomas Lee Collier, Perkasie, PA (US);

Tieming Zhao, Los Angeles, CA (US);

Chunfang Xia, Los Angeles, CA (US);

Assignee:

Siemens Medical Solutions USA, Inc., Malvern, PA (US);

Attorney:

Joshua Ryan

Primary Examiner:

Susannah Chung

Int. Cl.
CPC ...
A61K 51/00 (2006.01); C07D 343/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents.

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