The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 02, 2010
Filed:
Sep. 19, 2007
Min A. Xiang, Bridgewater, NJ (US);
Mona Patel, Belle Mead, NJ (US);
Philip Rybczynski, Somerville, NJ (US);
Joseph Gunnet, Flemington, NJ (US);
Keith T. Demarest, Flemington, NJ (US);
Richard Look, Trenton, NJ (US);
Bruce Maryanoff, Forest Grove, PA (US);
Michael J. Costanzo, Ivyland, PA (US);
Stephen C. Yabut, Perkasie, PA (US);
Min A. Xiang, Bridgewater, NJ (US);
Mona Patel, Belle Mead, NJ (US);
Philip Rybczynski, Somerville, NJ (US);
Joseph Gunnet, Flemington, NJ (US);
Keith T. Demarest, Flemington, NJ (US);
Richard Look, Trenton, NJ (US);
Bruce Maryanoff, Forest Grove, PA (US);
Michael J. Costanzo, Ivyland, PA (US);
Stephen C. Yabut, Perkasie, PA (US);
Janssen Pharmaceutica NV, Beerse, BE;
Abstract
The invention is directed to nonpeptide substituted spiroheterobenzazepine of Formula I, which are useful as vasopressin receptor antagonists for treating conditions associated with vasopressin receptor activity such as those involving increased vascular resistance and cardiac insufficiency, including congestive heart failure, hyponatremia, and hypertension. Pharmaceutical compositions comprising a compound of Formula I and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, hyponatremia, renal vasospasm, renal failure, diabetic nephropathy, cerebral edema, cerebral ischemia, stroke, thrombosis, or water retention are also disclosed.