The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 02, 2010
Filed:
Aug. 27, 2004
Shinji Nakade, Tsukuba, JP;
Hirotaka Mizuno, Tsukuba, JP;
Takeji Ono, Tsukuba, JP;
Masashi Minami, Tsukuba, JP;
Hiroshi Saga, Tsukuba, JP;
Hiroshi Hagiya, Tsukuba, JP;
Takaki Komiya, Tsukuba, JP;
Hiromu Habashita, Mishima-gun, JP;
Haruto Kurata, Mishima-gun, JP;
Kazuhiro Ohtsuki, Mishima-gun, JP;
Kensuke Kusumi, Mishima-gun, JP;
Shinji Nakade, Tsukuba, JP;
Hirotaka Mizuno, Tsukuba, JP;
Takeji Ono, Tsukuba, JP;
Masashi Minami, Tsukuba, JP;
Hiroshi Saga, Tsukuba, JP;
Hiroshi Hagiya, Tsukuba, JP;
Takaki Komiya, Tsukuba, JP;
Hiromu Habashita, Mishima-gun, JP;
Haruto Kurata, Mishima-gun, JP;
Kazuhiro Ohtsuki, Mishima-gun, JP;
Kensuke Kusumi, Mishima-gun, JP;
Ono Pharmaceutical Co., Ltd., Osaka, JP;
Abstract
A compound having an ability to bind to an S1P receptor (particularly EDG-6, preferably EDG-1 and EDG-6), for example, the compound represented by formula (I) of the present invention, a salt thereof, a solvate thereof or a prodrug thereof is useful for prevention and/or treatment of rejection of transplantation, graft-versus-host disease, autoimmune disease, allergic disease and the like. wherein ring A is a cyclic group; ring B is a cyclic group which may have substituent(s); X is a spacer having 1 to 8 atoms in its main chain, etc.; Y is a spacer having 1 to 10 atoms in its main chain, etc.; n is 0 or 1, wherein when n is 0, m is 1 and Ris a hydrogen atom or a substituent, and wherein when n is 1, m is 0 or an integer of 1 to 7 and Ris a substituent, and wherein m is 2 or more, Rs are the same or different.