The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 02, 2010
Filed:
Oct. 18, 2000
David J. Fitzgerald, Rockville, MD (US);
Randall J. Mrsny, Los Altos Hills, CA (US);
Marian Mckee, Great Falls, VA (US);
Ann Daugherty, Los Altos Hills, CA (US);
David J. FitzGerald, Rockville, MD (US);
Randall J. Mrsny, Los Altos Hills, CA (US);
Marian McKee, Great Falls, VA (US);
Ann Daugherty, Los Altos Hills, CA (US);
The United States of America as represented by the Department of Health and Human Services, Washington, DC (US);
Genentech, Inc., South San Francisco, CA (US);
Abstract
This invention provides bioactive conjugates. The bioactive conjugates include: (1) a cell recognition moiety that binds to αmacroglobulin receptor α2-MR and (2) a bioactive moiety which: (a) has a biological activity, (b) does not function solely as an immunogen to invoke an immune response and (c) does not have ADP ribosylating activity. The bioactive conjugates of this invention are useful in methods of transporting the bioactive moiety across a polar epithelial membrane. Thus, this invention provides methods for parenteral administration of proteins without injection.