The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 02, 2010
Filed:
Aug. 01, 2008
Thierry O. Fischmann, Scotch Plains, NJ (US);
Vincent S. Madison, Ukiah, CA (US);
Alan William Hruza, Hackettstown, NJ (US);
Paul Reichert, Montville, NJ (US);
Lata Ramanathan, Cambridge, NJ (US);
David Paul Sanden, San Francisco, CA (US);
Wolfgang Seghezzi, Mountain View, CA (US);
Thierry O. Fischmann, Scotch Plains, NJ (US);
Vincent S. Madison, Ukiah, CA (US);
Alan William Hruza, Hackettstown, NJ (US);
Paul Reichert, Montville, NJ (US);
Lata Ramanathan, Cambridge, NJ (US);
David Paul Sanden, San Francisco, CA (US);
Wolfgang Seghezzi, Mountain View, CA (US);
Schering Corp., Kenilworth, NJ (US);
Abstract
The present invention discloses nucleic acids that encode an active human Aurora 2 kinase catalytic domain. The present invention also discloses methods of growing X-ray diffractable crystals of polypeptides comprising the active human Aurora 2 kinase catalytic domain. The present invention further discloses a crystalline form of a catalytic domain of human Aurora 2 kinase. In addition, the present invention discloses methods of using the X-ray diffractable crystals of human Aurora 2 kinase in structure assisted drug design to identify compounds that can modulate the enzymatic activity of human Aurora 2 kinase.