The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 26, 2010
Filed:
Feb. 19, 2008
Stephen J. Benkovic, State College, PA (US);
Marc Ostermeier, Baltimore, MD (US);
Stefan Lutz, State College, PA (US);
Andrew E. Nixon, Quincy, MA (US);
Stephen J. Benkovic, State College, PA (US);
Marc Ostermeier, Baltimore, MD (US);
Stefan Lutz, State College, PA (US);
Andrew E. Nixon, Quincy, MA (US);
The Penn State Research Foundation, University Park, PA (US);
Abstract
A series of methods that utilize the incremental truncation of nucleic acids are described to create a plurality of modified nucleic acids and hybrid polypeptides. A plurality of substantially all possible single base-pair deletions of a given nucleic acid sequence is created. A method of making shuffled incremental truncated nucleic acids, which is independent of nucleic acid sequence homology, is also described. These methods can be used in protein engineering, protein folding, protein evolution, and the chemical synthesis of novel hybrid proteins and polypeptides.