The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 26, 2010
Filed:
Nov. 07, 2007
Kenji Kadomatsu, Aichi, JP;
Mitsuru Horiba, Aichi, JP;
Takashi Muramatsu, Aichi, JP;
Shinya Ikematsu, Kanagawa, JP;
Sadatoshi Sakuma, Kanagawa, JP;
Kenji Kadomatsu, Aichi, JP;
Mitsuru Horiba, Aichi, JP;
Takashi Muramatsu, Aichi, JP;
Shinya Ikematsu, Kanagawa, JP;
Sadatoshi Sakuma, Kanagawa, JP;
Medical Therapies Limited, Sydney, AU;
Abstract
The present invention provides a pharmaceutical composition for the prevention or treatment of angiostenosis, comprising a compound inhibiting the function of midkine (MK) in blood vessel tissues as an effective ingredient. The present invention is useful for the prevention or treatment of angiostenosis attributed to arteriosclerosis or restenosis after percutaneous transluminal coronary angioplasty (PTCA). As compounds inhibiting the function of MK, antisense oligonucleotides that bind to a segment of a single-stranded mRNA transcribed from the MK gene to inhibit the synthesis of MK protein in cells, antibodies against the MK protein, and such can be used.