The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 26, 2010
Filed:
Apr. 16, 2004
John S. Althaus, Saline, MI (US);
Lee Kyonghoon, Ann Arbor, MI (US);
Vijay Namasivayam, Ann Arbor, MI (US);
Sundaresh N. Brahmasandra, Ann Arbor, MI (US);
Kalyan Handique, Ann Arbor, MI (US);
John S. Althaus, Saline, MI (US);
Lee Kyonghoon, Ann Arbor, MI (US);
Vijay Namasivayam, Ann Arbor, MI (US);
Sundaresh N. Brahmasandra, Ann Arbor, MI (US);
Kalyan Handique, Ann Arbor, MI (US);
HandyLab, Inc., Ann Arbor, MI (US);
Abstract
The present invention relates to an electrochemical method for detecting a target polynucleotide. An electrode comprising an electrode surface is provided. The electrode surface includes at least one probe molecule reversibly immobilized with respect to the electrode surface. A first electrochemical signal indicative of an amount of probe molecule immobilized with respect to the electrode surface is obtained. The electrode surface is contacted with a liquid comprising the target polynucleotide. Upon the contacting step, at least some of the probe molecule immobilized with respect to the electrode surface dissociates therefrom. A second electrochemical signal indicative of an amount of probe molecule immobilized with respect to the electrode surface is obtained. The presence of the target polynucleotide is determined at least partially on the basis of the first and second electrochemical signals.