The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 19, 2010
Filed:
Mar. 15, 2002
Klaus Sommermeyer, Rosbach, DE;
Wolfram Eichner, Butzbach, DE;
Sven Frie, Bramois, CH;
Cornelius Jungheinrich, Bad Homburg, DE;
Roland Scharpf, Ranstadt, DE;
Katharina Lutterbeck, Friedberg, DE;
Jurgen Hemberger, Aschaffenburg, DE;
Michele Orlando, The Hague, NL;
Klaus Sommermeyer, Rosbach, DE;
Wolfram Eichner, Butzbach, DE;
Sven Frie, Bramois, CH;
Cornelius Jungheinrich, Bad Homburg, DE;
Roland Scharpf, Ranstadt, DE;
Katharina Lutterbeck, Friedberg, DE;
Jurgen Hemberger, Aschaffenburg, DE;
Michele Orlando, The Hague, NL;
Fresenius Kabi Deutschland GmbH, Bad Homburg v.d.H., DE;
Abstract
The invention relates to compounds, comprising a conjugate of hydroxyalkyl starch (HAS) and an active agent, whereby the hydroxyalkyl starch is either directly covalently bonded to the active agent, or by means of a linker. The invention further relates to methods for the production of a covalent HAS-active agent conjugate, whereby HAS and an active agent are reacted in a reaction medium, characterised in that the reaction medium is water or a mixture of water and an organic solvent, comprising at least 10 wt. % water.