The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 19, 2010
Filed:
Mar. 12, 2009
Brian M. Aquila, Marlborough, MA (US);
Thomas D. Bannister, Northborough, MA (US);
Gregory D. Cuny, Somerville, MA (US);
James R. Hauske, Concord, MA (US);
Joanne M. Holland, Brookline, MA (US);
Paul E. Persons, Westborough, MA (US);
Heike Radeke, South Grafton, MA (US);
Fengjiang Wang, Northborough, MA (US);
Liming Shao, Lincoln, MA (US);
Brian M. Aquila, Marlborough, MA (US);
Thomas D. Bannister, Northborough, MA (US);
Gregory D. Cuny, Somerville, MA (US);
James R. Hauske, Concord, MA (US);
Joanne M. Holland, Brookline, MA (US);
Paul E. Persons, Westborough, MA (US);
Heike Radeke, South Grafton, MA (US);
Fengjiang Wang, Northborough, MA (US);
Liming Shao, Lincoln, MA (US);
Sepracor Inc., Marlborough, MA (US);
Abstract
One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, serotonin, or norepinephrine transporters. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, schizophrenia, Parkinson's disease, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine transporters.