The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 19, 2010
Filed:
Mar. 20, 2006
Applicants:
Ronald Vogels, Linschoten, NL;
Menzo Jans Emco Havenga, Alphen aan den Rijn, NL;
David Adrianus Theodorus Maria Zuijdgeest, The Hague, NL;
Inventors:
Ronald Vogels, Linschoten, NL;
Menzo Jans Emco Havenga, Alphen aan den Rijn, NL;
David Adrianus Theodorus Maria Zuijdgeest, The Hague, NL;
Assignee:
Crucell Holland B.V., Leiden, NL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 19/34 (2006.01); C12N 7/00 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
In the absence of substantial sequence overlap between a recombinant adenoviral vector and the genome of a packaging cell, helper-dependent E1-containing particles (HDEP) can be formed at low frequency. The invention provides means and methods reducing or preventing the generation of HDEP. To this purpose, novel packaging cells and methods of making these are provided.