The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 19, 2010
Filed:
Aug. 03, 2007
Fusao Makishima, Tokyo, JP;
Hiroyuki Takamatsu, Saitama, JP;
Hideo Miki, Saitama, JP;
Shinji Kawai, Saitama, JP;
Michio Kimura, Saitama, JP;
Tomoaki Matsumoto, Saitama, JP;
Mieko Katsuura, Tokyo, JP;
Koichi Enomoto, Saitama, JP;
Yusuke Satoh, Saitama, JP;
Fusao Makishima, Tokyo, JP;
Hiroyuki Takamatsu, Saitama, JP;
Hideo Miki, Saitama, JP;
Shinji Kawai, Saitama, JP;
Michio Kimura, Saitama, JP;
Tomoaki Matsumoto, Saitama, JP;
Mieko Katsuura, Tokyo, JP;
Koichi Enomoto, Saitama, JP;
Yusuke Satoh, Saitama, JP;
Abstract
A protein having amino acid sequence in SEQ ID No.:1 of the Sequence Listing derived from human MP52, and a dimer protein thereof. A homodimer protein described above can be obtained by constructing a plasmid containing DNA coding amino acid sequence in SEQ ID No.:1 of the Sequence Listing with a methionine at the N-terminus, introducing the plasmid intofor transformation, solubilizing inclusion bodies obtained by culturing the transformant, purifying the monomer protein from the solubilized solution, refolding the monomer protein into a dimer protein and purifying the same. The homodimer protein described above is useful as a pharmaceutical composition for treating cartilage and bone diseases.