The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 19, 2010
Filed:
Jun. 21, 2002
Naima Mezaache, McLean, VA (US);
Steven E. Frisbee, Reston, VA (US);
Patrick B. Woodall, Culpeper, VA (US);
Mark R. Herman, Nokesville, VA (US);
Djelila Mezaache, Aldie, VA (US);
Naima Mezaache, McLean, VA (US);
Steven E. Frisbee, Reston, VA (US);
Patrick B. Woodall, Culpeper, VA (US);
Mark R. Herman, Nokesville, VA (US);
Djelila Mezaache, Aldie, VA (US);
Biovail Laboratories International SRL, St. Michael, BB;
Abstract
The invention provides a composition useful for making oral dosage forms capable of dissolving in the mouth in less than 40 seconds without the need for a conventional super disintegrant and having a friability of less than 1%; wherein the composition includes liquiflash particles and an excipient mass. A preferred excipient mass according to the invention contains a directly compressible inorganic salt; a cellulose derivative or a combination of a directly compressible inorganic salt and a cellulose derivative. Preferably, the liquiflash particles and the excipient mass are combined in proportions such that the active ingredient remains substantially within the microspheres when the composition is compressed to obtain a dosage form having a hardness of 20 to 50 N. The compositions of the invention allow for the fabrication of oral dosages having improved hardness and friability.