The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 19, 2010
Filed:
Jan. 29, 2007
Alon M. Chen, Rehovot, IL;
Kuo-fen Lee, Del Mar, CA (US);
Chien LI, Charlottesville, VA (US);
Wylie W. Vale, La Jolla, CA (US);
Alon M. Chen, Rehovot, IL;
Kuo-Fen Lee, Del Mar, CA (US);
Chien Li, Charlottesville, VA (US);
Wylie W. Vale, La Jolla, CA (US);
Research Development Foundation, Carson City, NV (US);
Abstract
In some aspects, the invention relates to methods for increasing insulin-sensitivity and/or decreasing insulin secretion in an individual by reducing or inhibiting corticotropin releasing factor 2 (CRFR2) signaling. CRFR2 antagonists may block agonism by one or more CRFR2 agonist, for example Ucn 2 or Ucn 3. Methods according to the invention may be use to treat a variety of metabolic diseases such as type 2 diabetes, metabolic syndrome, nonalcoholic fatty liver disease, polycystic ovarian syndrome and obesity.