The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 12, 2010
Filed:
Sep. 07, 2005
Gary S. Stein, Shrewsbury, MA (US);
Daniel W. Young, Sutton, MA (US);
Sayyed K. Zaidi, Worcester, MA (US);
Amjad Javed, Hoover, AL (US);
Andre J. Van Wijnen, Auburn, MA (US);
Janet L. Stein, Shrewsbury, MA (US);
Jane B. Lian, Westborough, MA (US);
Gary S. Stein, Shrewsbury, MA (US);
Daniel W. Young, Sutton, MA (US);
Sayyed K. Zaidi, Worcester, MA (US);
Amjad Javed, Hoover, AL (US);
Andre J. Van Wijnen, Auburn, MA (US);
Janet L. Stein, Shrewsbury, MA (US);
Jane B. Lian, Westborough, MA (US);
University of Massachusetts, Boston, MA (US);
Abstract
The present invention provides a method useful for analysis of punctate distribution of supramolecular complexes that are compartmentalized in nuclear microenvironments. In preferred embodiments the method provides quantitative analysis of the assembly of regulatory machinery within the context of nuclear architecture and to provide a mechanistic link with biological control. In other embodiments, the invention provides a method of identifying a molecule by parameters of its subnuclear distribution, comprising the steps of quantifying organizational parameters of domains within subnuclear distributions of a molecule; performing factor analysis on the quantified organizational parameters; performing discriminant analysis on the quantified organizational parameters; comparing the results of the factor analysis and the results of the discriminant analysis to one or more standards, thereby identifying a molecule by parameters of its subnuclear distribution.