The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 12, 2010

Filed:

Aug. 21, 2008
Applicants:

Philippe Jablonski, Steinbrunn-le-Haut, FR;

Kenichi Kawasaki, Kanagawa-ken, JP;

Henner Knust, Rheinfelden, DE;

Anja Limberg, Basel, CH;

Matthias Nettekoven, Grenzach-Wyhlen, DE;

Hasane Ratni, Habsheim, FR;

Claus Riemer, Freiburg, DE;

Xihan Wu, Shanghai, CN;

Inventors:

Philippe Jablonski, Steinbrunn-le-Haut, FR;

Kenichi Kawasaki, Kanagawa-ken, JP;

Henner Knust, Rheinfelden, DE;

Anja Limberg, Basel, CH;

Matthias Nettekoven, Grenzach-Wyhlen, DE;

Hasane Ratni, Habsheim, FR;

Claus Riemer, Freiburg, DE;

Xihan Wu, Shanghai, CN;

Assignee:

Hoffmann-La Roche Inc., Nutley, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/496 (2006.01); A61K 31/454 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); C07D 207/12 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 487/04 (2006.01); C07D 491/107 (2006.01);
U.S. Cl.
CPC ...
Abstract

The invention relates to a compound of general formula wherein are as defined herein or to a pharmaceutically active salt thereof, including all stereoisomeric forms, individual diastereoisomers and enantiomers of the compound of formula (I) as well as racemic and non-racemic mixtures thereof. The compounds are high potential NK-3 receptor antagonists for the treatment of depression, pain, psychosis, Parkinson's disease, schizophrenia, anxiety and attention deficit hyperactivity disorder (ADHD).


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