The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 12, 2010
Filed:
Mar. 17, 2003
Thomas W. Dubensky, Jr., Del Mar, CA (US);
John M. Polo, Encinitas, CA (US);
Barbara A. Belli, San Diego, CA (US);
Sondra Schlesinger, St. Louis, MO (US);
Sergey A. Drvga, Fort Collins, CO (US);
Ilya Frolov, St. Louis, MO (US);
Thomas W. Dubensky, Jr., Del Mar, CA (US);
John M. Polo, Encinitas, CA (US);
Barbara A. Belli, San Diego, CA (US);
Sondra Schlesinger, St. Louis, MO (US);
Sergey A. Drvga, Fort Collins, CO (US);
Ilya Frolov, St. Louis, MO (US);
Novartis Vaccines & Diagnostics, Inc., Emeryville, CA (US);
Abstract
Isolated nucleic acid molecules are disclosed, comprising an alphavirus nonstructural protein gene which, when operably incorporated into a recombinant alphavirus particle, eukaryotic layered vector initiation system, or RNA vector replicon, has a reduced level of vector-specific RNA synthesis, as compared to wild-type, and the same or greater level of proteins encoded by RNA transcribed from the viral junction region promoter, as compared to a wild-type recombinant alphavirus particle. Also disclosed are RNA vector replicons, alphavirus vector constructs, and eukaryotic layered vector initiation systems which contain the above-identified nucleic acid molecules.