The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 12, 2010
Filed:
Dec. 19, 2005
Johan Hendrikus Verheijen, Berkel En Rodenrijs, NL;
Jan Roeland Occo Hanemaaijer, Voorhout, NL;
Natascha Alexandra Van Lent, Gorinchem, NL;
Johannes Hendrikus Nicolaas Lindeman, Noordwijkerhout, NL;
Mohamed Rahoef Daha, Leiderdorp, NL;
Johanna Roos, Katwijk, NL;
Johan Hendrikus Verheijen, Berkel En Rodenrijs, NL;
Jan Roeland Occo Hanemaaijer, Voorhout, NL;
Natascha Alexandra Van Lent, Gorinchem, NL;
Johannes Hendrikus Nicolaas Lindeman, Noordwijkerhout, NL;
Mohamed Rahoef Daha, Leiderdorp, NL;
Johanna Roos, Katwijk, NL;
Abstract
This invention relates to the field of determining, assaying or quantifying activity of components of the complement system. More particularly, the invention relates to methods for detecting the presence or level of activity in a sample of mannan-binding-lectin associated serine proteases (MASPs) or complexes of such proteases with lectins and to detection of the particular lectins themselves. Provided is a method for determining the activity of a MASP in a sample, comprising incubating the sample with a pro-urokinase comprising at its activation site the consensus sequence Arg/Leu/Gly-Yyy-Arg/Lys-Ile/Leu/Val-Zzz-Gly-Gly cleavable by a MASP, wherein Yyy can be any amino acid and Zzz is preferably an aliphatic amino acid, and determining proteolytic activation of said pro-urokinase.