The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 05, 2010
Filed:
Aug. 13, 2008
Aslam A. Malik, Cameron Park, CA (US);
Hasan Palandoken, Woodland, CA (US);
Joy A. Stringer, Folsom, CA (US);
Roland P. Carlson, Davis, CA (US);
John Leach, Gold River, CA (US);
Thomas G. Archibald, St. Thomas, VI;
Robert G. Miotke, Gold River, CA (US);
Aslam A. Malik, Cameron Park, CA (US);
Hasan Palandoken, Woodland, CA (US);
Joy A. Stringer, Folsom, CA (US);
Roland P. Carlson, Davis, CA (US);
John Leach, Gold River, CA (US);
Thomas G. Archibald, St. Thomas, VI;
Robert G. Miotke, Gold River, CA (US);
Ampac Fine Chemicals LLC, Rancho Cordova, CA (US);
Abstract
The present invention provides a new process for the preparation of 2R,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbuty1)-p-nitrobenzenesulfonylamide hydrochloride, wherein this compound is prepared directly from the chloromethylalcohol. Importantly, the process of the present invention results in higher yields of 2R,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride without sacrificing its purity. The processes of the present invention can be used to prepare not only the 2R,3S-derivative, but also the 2S,3S-, 2S,2R- and the 2R,3R-derivatives.