The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 05, 2010
Filed:
Apr. 01, 2005
Hitoshi Ikeya, Machida, JP;
Tadashi Morikawa, Machida, JP;
Koichi Takahashi, Machida, JP;
Noriyuki Izutani, Machida, JP;
Tatsuya Tamura, Gotenba, JP;
Akira Okamachi, Susono, JP;
Takenori Ishizawa, Gotenba, JP;
Haruhiko Sato, Gotenba, JP;
Yoshinobu Higuchi, Gotenba, JP;
Tatsuya Kato, Gotenba, JP;
Akie Honma, Gotenba, JP;
Hitoshi Ikeya, Machida, JP;
Tadashi Morikawa, Machida, JP;
Koichi Takahashi, Machida, JP;
Noriyuki Izutani, Machida, JP;
Tatsuya Tamura, Gotenba, JP;
Akira Okamachi, Susono, JP;
Takenori Ishizawa, Gotenba, JP;
Haruhiko Sato, Gotenba, JP;
Yoshinobu Higuchi, Gotenba, JP;
Tatsuya Kato, Gotenba, JP;
Akie Honma, Gotenba, JP;
Denki Kagaku Kogyo Kabushiki Kaisha, Tokyo, JP;
Abstract
An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint disorders. There is provided a hyaluronic acid-methotrexate conjugate useful for the treatment of joint disorders, wherein methotrexate is conjugated with a hydroxy group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids, and the linker is conjugated with the hyaluronic acid through a carbamate group.