The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 05, 2010

Filed:

Feb. 13, 2007
Applicants:

Yongqi Deng, Newton, MA (US);

Gerald W. Shipps, Jr., Stoneham, MA (US);

Alan Cooper, West Caldwell, NJ (US);

Yang Nan, Malden, MA (US);

Tong Wang, Cambridge, MA (US);

M. Arshad Siddiqui, Newton, MA (US);

Hugh Zhu, Scotch Plains, NJ (US);

Robert Sun, Berkeley Heights, NJ (US);

Joseph M. Kelly, Parlin, NJ (US);

Ronald Doll, Convent Station, NJ (US);

Jagdish Desai, Monroe Township, NJ (US);

James J-s Wang, Westfield, NJ (US);

Youhao Dong, Cambridge, MA (US);

Vincent Madison, Mountain Lakes, NJ (US);

LI Xiao, Cranbury, NJ (US);

Alan Hruza, Hackettstown, NJ (US);

Neng-yang Shih, Warren, NJ (US);

Inventors:

Yongqi Deng, Newton, MA (US);

Gerald W. Shipps, Jr., Stoneham, MA (US);

Alan Cooper, West Caldwell, NJ (US);

Yang Nan, Malden, MA (US);

Tong Wang, Cambridge, MA (US);

M. Arshad Siddiqui, Newton, MA (US);

Hugh Zhu, Scotch Plains, NJ (US);

Robert Sun, Berkeley Heights, NJ (US);

Joseph M. Kelly, Parlin, NJ (US);

Ronald Doll, Convent Station, NJ (US);

Jagdish Desai, Monroe Township, NJ (US);

James J-S Wang, Westfield, NJ (US);

Youhao Dong, Cambridge, MA (US);

Vincent Madison, Mountain Lakes, NJ (US);

Li Xiao, Cranbury, NJ (US);

Alan Hruza, Hackettstown, NJ (US);

Neng-Yang Shih, Warren, NJ (US);

Assignee:

Schering Corporation, Kenilworth, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61K 31/4025 (2006.01); A61K 31/496 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07D 413/12 (2006.01); C07D 417/06 (2006.01); C07D 417/12 (2006.01);
U.S. Cl.
CPC ...
Abstract

Disclosed are the ERK inhibitors of formula 1.0: and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substituents are as defined herein. Also disclosed are methods of treating cancer using the compounds of formula 1.0.


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