The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 05, 2010
Filed:
Oct. 31, 2005
Carolyn R. Bertozzi, Berkeley, CA (US);
Nicholas J. Agard, Berkeley, CA (US);
Jennifer A. Prescher, Berkeley, CA (US);
Jeremy Michael Baskin, Berkeley, CA (US);
Carolyn R. Bertozzi, Berkeley, CA (US);
Nicholas J. Agard, Berkeley, CA (US);
Jennifer A. Prescher, Berkeley, CA (US);
Jeremy Michael Baskin, Berkeley, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).