The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 05, 2010
Filed:
Feb. 09, 2004
Applicants:
Jay Grobler, Gwynedd, PA (US);
Osvaldo Flores, North Wales, PA (US);
Eric J. Markel, Lansdale, PA (US);
Inventors:
Jay Grobler, Gwynedd, PA (US);
Osvaldo Flores, North Wales, PA (US);
Eric J. Markel, Lansdale, PA (US);
Assignee:
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/00 (2006.01); C12Q 1/68 (2006.01); C12Q 1/70 (2006.01); C07H 21/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention features methods for producing HCV replicons using HCV encoding sequences from different isolates. The featured methods are based on the discovered importance of NS3 amino acid position 470 in conferring cell culture replication activity to different HCV isolates.