The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 05, 2010
Filed:
Feb. 27, 2007
Matic Legisa, Medvode, SI;
Mojca Bencina, Ljubljana, SI;
Gregor Tevz, Nazarje, SI;
Maja Capuder, Dob pri Domzalah, SI;
Tina Mlakar, Radovljica, SI;
Darija Oven, Ljubljana, SI;
Matic Legisa, Medvode, SI;
Mojca Bencina, Ljubljana, SI;
Gregor Tevz, Nazarje, SI;
Maja Capuder, Dob pri Domzalah, SI;
Tina Mlakar, Radovljica, SI;
Darija Oven, Ljubljana, SI;
Kemijski Institut, Ljubljana, SI;
Abstract
The invention deals with mutated truncated mt-pfkA gene encoding shorter fragment of 6-phosphofructo-1-kinase (PFK1), with no need for phosphorylation of the protein molecule for activation, that is not significantly inhibited by citric acid and/or its salts and ATP molecules. Active 49-52 kDa fragment encoded by mt-pfkA gene, retains positive regulatory properties of the native protein and is activated in the presence of specific activators, while citric acid and ATP, important metabolites that function as feed back inhibitors in higher organisms do not reduce its activity. The invention deals with the use of modified shorter fragment in biotechnological processes for fabricating primary and secondary metabolites.