The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 05, 2010
Filed:
Apr. 04, 2008
Hartmuth C. Kolb, Playa Del Rey, CA (US);
Joseph C. Walsh, Pacific Palisades, CA (US);
Umesh B. Gangadharmath, Los Angeles, CA (US);
Farhad Karimi, Canton, MA (US);
Henry Clifton Padgett, Hermosa Beach, CA (US);
Dhanalakshmi Kasi, Los Angeles, CA (US);
Zhiyong Gao, Los Angeles, CA (US);
Qianwa Liang, Hacienda Heights, CA (US);
Thomas Lee Collier, Perkasie, PA (US);
Brian A. Duclos, Kalamazoo, MI (US);
Tieming Zhao, Los Angeles, CA (US);
Hartmuth C. Kolb, Playa Del Rey, CA (US);
Joseph C. Walsh, Pacific Palisades, CA (US);
Umesh B. Gangadharmath, Los Angeles, CA (US);
Farhad Karimi, Canton, MA (US);
Henry Clifton Padgett, Hermosa Beach, CA (US);
Dhanalakshmi Kasi, Los Angeles, CA (US);
Zhiyong Gao, Los Angeles, CA (US);
Qianwa Liang, Hacienda Heights, CA (US);
Thomas Lee Collier, Perkasie, PA (US);
Brian A. Duclos, Kalamazoo, MI (US);
Tieming Zhao, Los Angeles, CA (US);
Siemens Medical Solutions USA, Inc., Malvern, PA (US);
Abstract
The present invention relates to novel radioactively labeled bioreducible tracers of Formula I useful for detecting hypoxic tumors or ischemic tissue in vivo. In one embodiment, the tracers consist of a 2-nitroimidazole moiety, a triazole, metabolically stable linker with pharmacokinetics enhancing substituents, and a radioisotope. The preferred in vivo imaging modality is positron emission tomography.