The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 28, 2010
Filed:
Mar. 14, 2007
John S. Olson, Houston, TX (US);
George N. Phillips, Jr., Madison, WI (US);
John S. Olson, Houston, TX (US);
George N. Phillips, Jr., Madison, WI (US);
William Marsh Rice University, Houston, TX (US);
Wisconsin Alumni Research Foundation, Madison, WI (US);
Abstract
The disclosure relates to recombinant adult human apohemoglobin (apo-rHb) in which the stability has been increased by replacement of an amino acid with a counterpart from another organism, such as a deep sea diving mammal. This mutated apo-rHb may be more stable and/or give higher production yields than unmutated adult human apo-rHb. The mutated apo-rHb may be produced in microorganisms, such asor yeast cells, or animal erythroid cells. Some apo-rHb of the present disclosure may be used as part of a blood substitute.