The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 28, 2010
Filed:
May. 01, 2007
Christopher John Love, Deurne, BE;
Guy Rosalia Eugeen Van Lommen, Berlaar, BE;
Julien Georges Pierre-olivier Doyon, Turnhout, BE;
Jean-pierre André Marc Bongartz, Turnhout, BE;
Marcel Jozef Maria Van Der Aa, Ravels, BE;
Robert Jozef Maria Hendrickx, Beerse, BE;
Peter Jacobus Johannes Antonius Buijnsters, Breda, NL;
Ludwig Paul Cooymans, Beerse, BE;
Nele Vandermaesen, Olmen, BE;
Erwin Coesemans, Nijlen, BE;
Gustaaf Maria Boeckx, Oud-Turnhout, BE;
Christopher John Love, Deurne, BE;
Guy Rosalia Eugeen Van Lommen, Berlaar, BE;
Julien Georges Pierre-Olivier Doyon, Turnhout, BE;
Jean-Pierre André Marc Bongartz, Turnhout, BE;
Marcel Jozef Maria Van der Aa, Ravels, BE;
Robert Jozef Maria Hendrickx, Beerse, BE;
Peter Jacobus Johannes Antonius Buijnsters, Breda, NL;
Ludwig Paul Cooymans, Beerse, BE;
Nele Vandermaesen, Olmen, BE;
Erwin Coesemans, Nijlen, BE;
Gustaaf Maria Boeckx, Oud-Turnhout, BE;
Janssen Pharmaceutica NV, , BE;
Abstract
This invention concerns the use of a compound of formula (I') a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein Z is halo; Calkyl; Calkylcarbonyl; Calkyloxycarbonyl; aminocarbonyl; Calkyl substituted with hydroxy, carboxyl, cyano, amino, amino substituted with piperidinyl, amino substituted with Calkyl substituted piperidinyl, mono- or di(Calkyl)amino, aminocarbonyl, mono- or di(Calkyl)aminocarbonyl, Calkyloxycarbonyl, Calkyloxy, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl; polyhaloCalkyl; cyano; amino; mono- or di(Calkyl)aminocarbonyl; Calkyloxycarbonyl; Calkylcarbonyloxy; aminoS(═O)—; mono- or di(Calkyl)aminoS(═O); —C(═N—R)NRR; Q is optionally substituted Ccycloalkyl, phenyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazinyl, benzthiazolyl, benzoxazolyl, benzimidazolyl, indazolyl, or imidazopyridyl, or Q is a radical of formula L is optionally substituted phenyl or an optionally substituted monocyclic 5 or 6-membered partially saturated or aromatic heterocycle or a bicyclic partially saturated or aromatic heterocycle; aryl is optionally substituted phenyl; for the manufacture of a medicament for the prevention or the treatment of inflammatory and/or auto-immune diseases mediated through TNF-α and/or IL-12.